Dermatological E45 Cream. Treatment for Dry Skin Conditions. Effective and pleasant to use, E45 Cream has been clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, sunburn and detergent hands. Its non-greasy emollient formulation is quickly absorbed by your skin, leaving it soft, comfortable and relieved. Perfume free, Dermatologically tested, clinically proven.